Monashees, the São Paulo-based venture firm that shaped Latin America's startup ecosystem over two decades, has planted a flag in Silicon Valley with a new San Francisco office. The move signals the firm's bet that the region's most ambitious founders now need Bay Area connections to scale globally.

Partner Fabiola Quinzaños leads the expansion, reflecting Monashees' strategic shift from pure regional investor to transnational operator. The firm has backed over 100 companies across Latin America, including major exits and category leaders. Now it confronts a hard reality: founders graduating from Monashees' portfolio eventually need US capital, US talent, and US customer access to reach unicorn scale.

The San Francisco office addresses this head-on. Rather than let portfolio companies shop for new investors elsewhere, Monashees keeps them in-house through expansion rounds. For the firm, this locks in ownership and deepens founder relationships. For founders, it means staying connected to investors who understand their DNA rather than starting cold conversations with Sand Hill Road generalists.

The timing reflects AI's reshaping of venture geography. Latin America produces strong software engineers and founders with deep local expertise, but the region lacks the concentration of AI infrastructure, chips, and computational resources flooding Silicon Valley. Teams building AI-first products face pressure to relocate or partner with US firms. Monashees' SF presence lets it scout talent, monitor the AI build-out, and position portfolio companies at this infrastructure crossroads.

This strategy echoes what Andreessen Horowitz and Sequoia did decades ago, establishing footholds globally while maintaining San Francisco gravity. For Monashees, the play is inverted: it's a regional champion extending northward rather than a US giant going south.

The firm still anchors in Latin America, where founder density and market size continue rising. But founders with global ambitions now get Mon